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300260

Diphenyleneiodonium Chloride

≥97% (HPLC), crystalline solid, eNOS inhibitor, Calbiochem®

Synonim(y):

Diphenyleneiodonium Chloride, DPI

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Do Państwa/SKUDostępnośćCena netto
10 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

471,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C12H8ClI
Numer CAS:
4673-26-1
Masa cząsteczkowa:
314.55
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00214165
Assay:
≥97% (HPLC)
Form:
crystalline solid
Storage condition:
OK to freeze, protect from light

471,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Nazwa produktu

Diphenyleneiodonium Chloride, A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

Quality Segment

100

assay

≥97% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[I+]1c2c(cccc2)c3c1cccc3.[Cl-]

InChI

1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1

InChI key

FCFZKAVCDNTYID-UHFFFAOYSA-M

General description

A cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50 = 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system.
A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
eNOS
Product does not compete with ATP.
Reversible: no
Target IC50: 180 nM against endothelial nitric oxide synthase (eNOS)

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubility.

Other Notes

Wang, Y.X., et al. 1995. Br. J. Pharmacol.114, 194.
Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
Wang, Y.X., et al. 1993. Br. J. Pharmacol.110, 1232.
Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol.109, 1186.
Stuehr, D.J., et al. 1991. FASEB J.5, 98.
Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J.242, 103.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)
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Ta pozycja
D2926311204400600
Diphenyleneiodonium Chloride A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

Sigma-Aldrich

300260

Diphenyleneiodonium Chloride

Diphenyleneiodonium chloride ≥98%

Sigma-Aldrich

D2926

Diphenyleneiodonium chloride

NG,NG′-Dimethyl-L-arginine, Dihydrochloride Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.

Sigma-Aldrich

311204

NG,NG′-Dimethyl-L-arginine, Dihydrochloride

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.

Sigma-Aldrich

400600

L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride

description

A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

description

≥98%

description

Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.

description

A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.

form

crystalline solid

form

powder

form

solid

form

solid

assay

≥97% (HPLC)

assay

≥98%

assay

≥97% (HPLC)

assay

≥98% (TLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

storage condition

protect from light, OK to freeze

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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