N7004

β-Nicotinamide adenine dinucleotide hydrate

≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

• Synonim(y): β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide
• Wzór empiryczny (zapis Hilla): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
• Numer CAS: 53-84-9
• Masa cząsteczkowa: 663.43 (anhydrous basis)
• Numer MDL: MFCD00036253
• Kod UNSPSC: 41106305
• eCl@ss: 39200202
• Identyfikator substancji w PubChem: 24897803
• NACRES: NA.55

Właściwości

• pochodzenie biologiczne: yeast
• Poziom jakości: 300
• Próba: ≥96.5% (HPLC); ≥96.5% (spectrophotometric assay)
• Postać: powder
• wynik ekologicznej alternatywy: old score: 56; new score: 20; Find out more about DOZN™ Scoring
• charakterystyka ekologicznej alternatywy: Waste Prevention; Less Hazardous Chemical Syntheses; Safer Solvents and Auxiliaries; Design for Energy Efficiency; Use of Renewable Feedstocks; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• kolor: white to off-white
• Zastosowanie: metabolomics
• kategoria ekologicznej alternatywy: Re-engineered,
• temp. przechowywania: −20°C
• ciąg SMILES: NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
• Klucz InChI: BAWFJGJZGIEFAR-NNYOXOHSSA-N
• informacje o genach: human ... ESR1(2099) , ESR2(2100)

Opis

Opis ogólny

Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme that transcends its traditional role as an "electron carrier," influencing diverse cellular processes. In cell biology, NAD operates as a crucial electron acceptor in the electron transport chain, driving the production of ATP, the cell′s primary energy source. This electron flow sustains basic cellular maintenance and complex signaling pathways. Beyond its energetic role, NAD serves as a dynamic signaling molecule, dictating cellular responses to various stimuli. Fluctuations in NAD concentration trigger events in DNA repair, gene expression, and cell death, allowing cells to adapt to stress and maintain homeostasis.

In biochemical research, NAD emerges as a vital cofactor for enzymes like sirtuins, poly(ADP-ribose) polymerases, and cADP-ribose synthases. These enzymes rely on NAD+ for catalytic activity, influencing processes such as protein deacetylation, DNA repair, and cellular signaling. In metabolomics, NAD plays a key role in metabolic pathways, making it a significant focus for understanding cellular metabolism comprehensively. NAD participates in additional intricate cellular processes, serving as a substrate for ADP-ribosylation—a post-translational modification affecting protein function. It also acts as a precursor for cyclic ADP-ribose, a second messenger molecule involved in calcium mobilization and cell communication. Research on NAD holds promise across various areas, including aging, where its role is actively investigated. Studies also explore its implications in neurodegenerative disorders and metabolic imbalances.

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency”, “Use of Renewable Feedstocks” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Zastosowanie

β-Nicotinamide adenine dinucleotide hydrate has been used:

• to prepare NAD+ standard solution for a study on NAD+ metabolomics
• as a component of MurI assay reaction partial mixture for glutamate racemase reaction
• as a component of a chromogenic staining solution to stain zebrafish embryos

Działania biochem./fizjol.

Electron acceptor

Cechy i korzyści

Versatile and adaptable for a wide variety of laboratory and research applications.

Opakowanie

Packaged by solid weight.

Uwaga dotycząca przygotowania

To prepare a solution gentle heating and sonication may be necessary.

Inne uwagi

This is the common form of NAD.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable