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Dokumenty

E1271

Sigma-Aldrich

N-Ethylmaleimide

BioXtra, ≥98% (HPLC)

Synonim(y):

NEM

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About This Item

Wzór empiryczny (zapis Hilla):
C6H7NO2
Numer CAS:
128-53-0
Masa cząsteczkowa:
125.13
Beilstein:
112448
Numer WE:
204-892-4
Numer MDL:
MFCD00005509
Kod UNSPSC:
12352106
Identyfikator substancji w PubChem:
24894398
NACRES:
NA.21

linia produktu

BioXtra

Próba

≥98% (HPLC)

zanieczyszczenia

≤0.001% Phosphorus (P)
≤0.1% Insoluble matter

pozostałość po prażeniu

≤0.1%

tw

210 °C (lit.)

mp

43-46 °C (lit.)

rozpuszczalność

95% ethanol: 50 mg/mL, clear to slightly hazy (colorless to faint yellow)

ślady anionów

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

ślady kationów

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

temp. przechowywania

2-8°C

ciąg SMILES

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

Klucz InChI

HDFGOPSGAURCEO-UHFFFAOYSA-N

informacje o genach

human ... SLC6A3(6531) , SLC6A4(6532)

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Zastosowanie

Reagent for the covalent modification of cysteine residues in proteins.

Działania biochem./fizjol.

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesCorrosion
GHS06,GHS05

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300,H311,H314,H317

Klasyfikacja zagrożeń

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

163.2 °F - closed cup

Temperatura zapłonu (°C)

72.9 °C - closed cup

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCV1969
MKCQ8782
MKCQ8783
MKCS3090
MKCM9140

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Tatsuki Kurokawa et al.
Biochimica et biophysica acta, 1838(1 Pt B), 382-387 (2013-10-22)
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Nicolas Matuszak et al.
Journal of medicinal chemistry, 52(23), 7410-7420 (2009-07-09)
The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have
Hannah E Boycott et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), E3955-E3964 (2013-09-26)
Atrial myocytes are continuously exposed to mechanical forces including shear stress. However, in atrial myocytes, the effects of shear stress are poorly understood, particularly with respect to its effect on ion channel function. Here, we report that shear stress activated
Marc Cuesta et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1360-1370 (2014-12-17)
In humans, shift work induces a desynchronization between the circadian system and the outside world, which contributes to shift work-associated medical disorders. Using a simulated night shift experiment, we previously showed that 3 d of bright light at night fully
Florian A Salomons et al.
Molecular and cellular biology, 29(7), 1774-1785 (2009-01-23)
Conditions causing an increase in misfolded or aberrant proteins can impair the activity of the ubiquitin/proteasome system (UPS). This observation is of particular interest, given the fact that proteotoxic stress is closely associated with a large variety of disorders. Although
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