P118

ファクロフェン

solid

• 別名: 3-アミノ-2-(4-クロロフェニル)プロパンホスホン酸
• 実験式（ヒル表記法）: C₉H₁₃ClNO₃P
• CAS番号: 114012-12-3
• 分子量: 249.63
• MDL番号: MFCD00069328
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278189
• NACRES: NA.32

特性

• フォーム: solid
• 不純物: ≥97% (NMR)
• 色: white
• 溶解性: 0.1 M HCl: 13.3 mg/mL; methanol: 19.3 mg/mL; DMSO: insoluble
• SMILES記法: NCC(CP(O)(O)=O)c1ccc(Cl)cc1
• InChI: 1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
• InChI Key: VSGNGLJPOGUDON-UHFFFAOYSA-N
• 遺伝子情報: human ... GABBR1(2550) , GABBR2(9568)

詳細

詳細

Phaclofen is a phosphonic acid derivative of baclofen.[1]

アプリケーション

Phaclofen has been used to block GABAB receptor.[2]

生物化学的／生理学的作用

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact.[1] Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K⁺ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.[3]

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves