WH0001656M1

Monoclonal Anti-DDX6 antibody produced in mouse

clone 3D2, purified immunoglobulin, buffered aqueous solution

• Szinonimák: Anti-DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, Anti-HLR2, Anti-P54, Anti-RCK
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: purified immunoglobulin
• antitest terméktípus: primary antibodies
• klón: 3D2, monoclonal
• form: buffered aqueous solution
• faj reaktivitás: human
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• izotípus: IgG1κ
• GenBank elérési szám: BC065007
• UniProt elérési szám: P26196
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... DDX6(1656)

Leírás

Általános leírás

DEAD-box helicase 6 (DDX6), also known as RCK/p54, is encoded by the gene mapped to human chromosome 11q23.3. The encoded protein belongs to the DEAD-box RNA helicase family.

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. (provided by RefSeq)

Immunogen

DDX6 (AAH65007, 1 a.a. ~ 483 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP

Biokémiai/fiziológiai hatások

DEAD-box helicase 6 (DDX6) is a key constituent of messenger ribonucleoprotein (mRNP) complexes. It facilitates the translation of mRNA in meiotic cells. DDX6 regulates adult progenitor cell function through differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs. Deletion of the gene leads to premature differentiation and decreased proliferation of epidermal progenitor cells. Elevated expression of the gene is associated with the development of colorectal tumors.

Fizikai forma

Solution in phosphate buffered saline, pH 7.4

Jogi információk

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Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)