T7383

Tetracaine

≥98% (TLC)

• Szinonimák: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₄N₂O₂
• CAS-szám: 94-24-6
• Molekulatömeg: 264.36
• EC-szám: 202-316-6
• MDL-szám: MFCD00053787
• UNSPSC kód: 12352200
• PubChem Substance ID: 57654695
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• Teszt: ≥98% (TLC)
• form: powder
• technika/technikák: toxicology assay: suitable
• tárolási hőmérséklet: 2-8°C
• SMILES string: CCCCNc1ccc(cc1)C(=O)OCCN(C)C
• InChI: 1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
• Nemzetközi kémiai azonosító kulcs: GKCBAIGFKIBETG-UHFFFAOYSA-N
• Géninformáció: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Leírás

Általános leírás

Tetracaine belongs to the amino-ester class and has a pKa of 8.46.

Alkalmazás

Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

Topical ophthalmic anesthetic; used for spinal anesthesia

Biokémiai/fiziológiai hatások

Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.

Blocks voltage-sensitive release of Ca²⁺ from sarcoplasmic reticulum.

Elkészítési megjegyzés

250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H317,H351
• Óvintézkedésre vonatkozó mondatok: P201 - P280 - P301 + P310 + P330 - P302 + P352
• Veszélyességi osztályok: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3