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T7154

Sigma-Aldrich

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

Szinonimák:

Laminin Fragment 929-933

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

Tapasztalati képlet (Hill-képlet):
C26H42N8O8
CAS-szám:
110590-64-2
Molekulatömeg:
594.66
MDL-szám:
MFCD00076472
UNSPSC kód:
12352209
PubChem Substance ID:
24900419
NACRES:
NA.32

biológiai forrás

synthetic (organic)

Minőségi szint

200

Teszt

≥97% (HPLC)

form

powder

technika/technikák

cell culture | mammalian: suitable

oldhatóság

H2O: soluble 1 mg/mL, clear, colorless

tárolási hőmérséklet

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1

Nemzetközi kémiai azonosító kulcs

MWOGMBZGFFZBMK-LJZWMIMPSA-N

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

Alkalmazás

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

Biokémiai/fiziológiai hatások

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

Elkészítési megjegyzés

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Arg-Gly-Asp ≥97% (TLC)

Sigma-Aldrich

A8052

Arg-Gly-Asp

MAPTRIX-L-YIGSR Laminin Mimetic, aqueous solution

Sigma-Aldrich

164142K

MAPTRIX-L-YIGSR

Silviya P Zustiak et al.
Acta biomaterialia, 6(9), 3404-3414 (2010-04-14)
Synthetic three-dimensional scaffolds for cell and tissue engineering routinely utilize peptide ligands to provide sites for cell adhesion and to promote cellular activity. Given the fact that recent studies have dedicated great attention to the mechanisms by which cell behavior
Jong Hyuk Yoon et al.
Biochemical and biophysical research communications, 428(3), 416-421 (2012-11-01)
The dermal ECM is synthesized from fibroblasts and is primarily compromised of fibrillar collagen and elastic fibers, which support the mechanical strength and resiliency of skin, respectively. Laminin, a major glycoprotein located in the basement membrane, promotes cell adhesion, cell
Rajeev K Sinha et al.
Journal of the American Society for Mass Spectrometry, 22(9), 1645-1650 (2011-09-29)
Charge-directed fragmentation has been shown to be the prevalent dissociation step for protonated peptides under the low-energy activation (eV) regime. Thus, the determination of the ion structure and, in particular, the characterization of the protonation site(s) of peptides and their
T Michigami et al.
Clinical & experimental metastasis, 16(7), 645-654 (1999-02-05)
B-cell lymphoma frequently shows simultaneous dissemination to multiple organs. It also occasionally involves bone and causes osteolytic lesions. To study the mechanisms responsible for this capacity of lymphoma cells to grow in different tissue microenvironments and search for effective therapeutic
Kazuyuki Fukushima et al.
Journal of medical and dental sciences, 55(1), 71-79 (2008-03-01)
We developed a honeycomb-shaped lyophilized Type I atelocollagen (Honeycomb Collagen: HC) with different pore sizes, and the effectiveness of the honeycomb shape on nerve regeneration was examined. We analyzed neurite outgrowth of dorsal root ganglion (DRG) explants on HC, both
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Cikkek

Conjugated Polymers for the Engineering of Device/Tissue Interface

Conjugated polymers offer charge transport between inorganic, electrically conducting metals and organic, proton-conducting biological systems.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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