SRP6158
EPO human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Szinonimák:
EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in HEK 293 cells
Teszt
≥95% (SDS-PAGE)
Forma
lyophilized
molekulatömeg
36 kDa (monomer, glycosylated)
kiszerelés
pkg of 10 μg
technika/technikák
cell culture | mammalian: suitable
NCBI elérési szám
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... EPO(2056)
Általános leírás
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.
Alkalmazás
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
- It has also been used as a component of endothelial differentiation medium.
Biokémiai/fiziológiai hatások
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.
Fizikai forma
Lyophilized from a PBS solution.
Elkészítési megjegyzés
Centrifuge the vial prior to opening.
Feloldás
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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