Összes fotó(1)
Fontos dokumentumok
SML1791
Urolithin A
≥97% (HPLC), powder, anti-inflammatory
Szinonimák:
3,8-Dihydroxy-6H-benzo[c]chromen-6-one
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C13H8O4
CAS-szám:
Molekulatömeg:
228.20
MDL-szám:
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
Terméknév
Urolithin A, ≥97% (HPLC)
Minőségi szint
Teszt
≥97% (HPLC)
Forma
powder
szín
white to beige
oldhatóság
DMSO: 20 mg/mL, clear
tárolási hőmérséklet
2-8°C
SMILES string
OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
Nemzetközi kémiai azonosító kulcs
RIUPLDUFZCXCHM-UHFFFAOYSA-N
Alkalmazás
Urolithin A has been used:
- to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay
- as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic cell death during ischemia-reperfusion (I/R) injury
- to study its inhibitory effect on epithelial-to-mesenchymal transition (EMT) in lung cancer cells via P53-Mdm2-Snail pathway
- to study its effects on streptozotocin-induced diabetic cardiomyopathy in rats by activating sirtuin 1/silent mating type information regulation 2 homolog 1 (SIRT1) signaling
Biokémiai/fiziológiai hatások
Urolithin A is a natural product with antiproliferative and antioxidant activity. Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin A has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.
Urolithin A is the most studied urolithin with anti-inflammatory and anti-obesity properties. It may also prevent the progression of various cancer types including colon, prostate, and bladder cancer by downregulating several oncogenes such as the mammalian target of rapamycin (mTOR) and Kirsten rat sarcoma viral oncogene(K-Ras), upregulating tumor suppressor genes such as p53 and epidermal growth factor receptor (EGFR) in various tumor pathways.
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Eye Irrit. 2 - Skin Irrit. 2
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Válasszon a legfrissebb verziók közül:
Analitikai tanúsítványok (COA)
Lot/Batch Number
Nem találja a megfelelő verziót?
Ha egy adott verzióra van szüksége, a tétel- vagy cikkszám alapján rákereshet egy adott tanúsítványra.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Az ügyfelek ezeket is megtekintették
Sheng-Long Ding et al.
Journal of inflammation (London, England), 17, 13-13 (2020-03-27)
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties
Antonio González-Sarrías et al.
European journal of nutrition, 56(2), 831-841 (2015-12-19)
Urolithins, metabolites produced by the gut microbiota from ellagic acid, have been acknowledged with cancer chemopreventive activity. Although urolithin A (Uro-A) has been reported to be the most active one, 10-50 % of humans can also produce the isomer isourolithin A
Abdulaziz Musa Alzahrani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and
Yun Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1107-1115 (2015-04-26)
The intestinal metabolites of ellagic acid (EA), urolithins are known to effectively inhibit cancer cell proliferation. This study investigates antiproliferative and antioxidant effects of urolithin A (UA) on cell survival of the HepG2 hepatic carcinomas cell line. The antiproliferative effects
Gadah Albasher et al.
Saudi journal of biological sciences, 29(2), 1210-1220 (2022-03-05)
This study examined the cardiac anti-cardiomyopathy (DC) protective effect of urolithin A in streptozotocin (STZ)-treated rats and investigated if this protection involves activation of SIRT1 signaling. Diabetes was induced first STZ (65 mg/kg, i.p.) before starting the experiments. Adult male rats
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
Lépjen kapcsolatba a szaktanácsadással