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SML0141

Sigma-Aldrich

Trilostane

≥98% (HPLC)

Szinonimák:

(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

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About This Item

Tapasztalati képlet (Hill-képlet):
C20H27NO3
CAS-szám:
13647-35-3
Molekulatömeg:
329.43
EC-szám:
237-133-0
MDL-szám:
MFCD00199295
UNSPSC kód:
51111800
PubChem Substance ID:
329825189
NACRES:
NA.77

Minőségi szint

100

Teszt

≥98% (HPLC)

Forma

powder

szín

white to tan

oldhatóság

DMSO: ≥17 mg/mL

tárolási hőmérséklet

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CC[C@@]45O[C@@H]4C(O)=C(C[C@]35C)C#N)[C@@H]1CC[C@@H]2O

InChI

1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

Nemzetközi kémiai azonosító kulcs

KVJXBPDAXMEYOA-CXANFOAXSA-N

Géninformáció

human ... HSD3B2(3284)

Általános leírás

Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.

Alkalmazás

Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.
Trilostane was used to inhibit the activity of 3β-hydroxysteroid dehydrogenase in mouse ovary.

Biokémiai/fiziológiai hatások

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids. It has been used in the treatment of Cushing′s syndrome for stopping the production of cortisol, and is currently approved for dogs in the US, but is still a human drug in the UK and other countries. It is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. It has also been used to inhibit endogenous production of progesterone in research studies.

Tulajdonságok és előnyök

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramok

Health hazardExclamation mark
GHS08,GHS07

Figyelmeztetés

Warning

Figyelmeztető mondatok

H315,H319,H361

Veszélyességi osztályok

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

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Analitikai tanúsítványok (COA)

Lot/Batch Number
0000082991
0000385837
0000378934
0000378935
0000378935

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Dokumentumtár megtekintése

Sex-Mediated Differences in LPS Induced Alterations of TNFalpha, IL-10 Expression, and Prostaglandin Synthesis in Primary Astrocytes
Chistyakov D ,et al.
International Journal of Molecular Sciences, 19(9), 2793-2793 (2018)
Chiemi Miura et al.
Reproduction (Cambridge, England), 142(6), 869-877 (2011-10-07)
Gh plays important roles in development, somatic growth and gametogenesis in vertebrates. To determine the physiological role of Gh in reproduction in male teleosts, the expression of genes encoding Gh and the two Gh receptors (Ghrs) during spermatogenesis, and the
Emily Cross et al.
Topics in companion animal medicine, 27(1), 8-20 (2012-09-11)
A 12-year-old female spayed domestic short-haired cat presented for lethargy, poor hair coat, alopecia, difficulty walking, and mild polyuria/polydipsia. The cat's skin tore easily in the neck area during routine restraint for blood draw. Physical examination, blood analysis, and ultrasound
J de Gier et al.
Theriogenology, 75(7), 1271-1279 (2011-02-08)
Interference with the pregnancy-maintaining influence of progesterone is the basis of most methods for termination of unwanted pregnancy in dogs. The currently available methods are based on induction of luteolysis or blocking of the progesterone receptor. Inhibition of progesterone synthesis
Minghui Li et al.
Cellular and molecular life sciences : CMLS, 77(23), 4921-4938 (2020-01-20)
A novel insulin-like growth factor (igf3), which is exclusively expressed in the gonads, has been widely identified in fish species. Recent studies have indicated that Igf3 regulates spermatogonia proliferation and differentiation in zebrafish; however, detailed information on the role of
View All Related Papers

Cikkek

Nuclear Receptors (Steroids)

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