SMB01000

Grandiflorenic acid

≥90% (LC/MS-ELSD)

• Szinonimák: (4S,5R,9R)-5,9-Dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadec-10-ene-5-carboxylic acid, Kaura-9(11),16-dien-18-oic acid
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₈O₂
• CAS-szám: 22338-67-6
• Molekulatömeg: 300.44
• MDL-szám: MFCD23103740
• UNSPSC kód: 12352205
• NACRES: NA.25

Tulajdonságok

• biológiai forrás: plant
• Teszt: ≥90% (LC/MS-ELSD)
• form: solid
• molekulatömeg: 300.44
• oldhatóság: water: slightly soluble
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: −20°C
• InChI: 1S/C20H28O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h6,14-15H,1,4-5,7-12H2,2-3H3,(H,21,22)/t14?,15-,18+,19+,20?/m0/s1
• Nemzetközi kémiai azonosító kulcs: RJIPNPHMQGDUBW-MZWQVCBVSA-N

Leírás

Általános leírás

Grandiflorenic acid, a diterpenoid, is a natural product commonly derived from Wedelia trilobata, Sphagneticola trilobata and Siegesbeckia orientalis L. It exhibits various biological activities such as anti-inflammatory, anti-depressant, anti-fertility, and anti-microbial properties.

Alkalmazás

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biokémiai/fiziológiai hatások

Grandiflorenic acid exhibits antibacterial, anti-inflammatory, antileishmanial and wound-healing properties.
Grandiflorenic acid shows moderate cytotoxic (IC50 15μM in RAW264.7 cells) and antiplasmodial activities (IC50 23μM against P. falciparum).

Grandiflorenic acid (GFA) shows promise as an anticancer agent by inhibiting cell proliferation and reducing cell size in breast (MCF7), lung (A549), and liver (HuH7.5) tumor cell lines. Further, it also shows effects on uterine motility throughout the estrus cycle suggesting it may have antifertility properties, possibly by affecting hormones and adrenergic pathways in the uterus.

Tulajdonságok és előnyök

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Egyéb megjegyzések

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Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable