Epitope mapping has not been conducted, so the exact binding site is unknown. However, the immunogen is located at aa128-247 (Accession# P23560).
Összes fotó(2)
Fontos dokumentumok
RAB0026
Human BDNF ELISA Kit
for serum, plasma, cell culture supernatant and urine
Szinonimák:
BDNF, Brain-derived neurotrophic factor
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
UNSPSC kód:
41116158
NACRES:
NA.32
Az árazás és az elérhetőség jelenleg nem elérhető
Javasolt termékek
faj reaktivitás
human
kiszerelés
kit of 96 wells (12 strips x 8 wells)
technika/technikák
ELISA: suitable
capture ELISA: suitable
bemenet
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.066-16 ng/mL
észlelési módszer
colorimetric
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... BDNF(627)
Általános leírás
The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.
The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1.[1] BDNF is a member of the neurotrophin family of growth factors.[2] The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play crucial roles in cellular signaling.[3]
Immunogén
Recombinant Human BDNF
Alkalmazás
For research use only. Not for use in diagnostic procedures.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats.[4] It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.[5]
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats.[4] It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.[5]
Biokémiai/fiziológiai hatások
Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions.[9] BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB).[10] It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.[3]
Egyéb megjegyzések
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Leírás
Biztonsági adatlap
- RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)Biztonsági adatlap
- RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)Biztonsági adatlap
- RABSTOP3ELISA Stop Solution (Item I)Biztonsági adatlap
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)Biztonsági adatlap
- RABWASH420X Wash Buffer (Item B)Biztonsági adatlap
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Met. Corr. 1
Tárolási osztály kódja
8A - Combustible corrosive hazardous materials
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Az ügyfelek ezeket is megtekintették
Oxidative Stress-Tolerant Stem Cells from Human Exfoliated Deciduous Teeth Decrease Hydrogen Peroxide-Induced Damage in Organotypic Brain Slice Cultures from Adult Mice
Xiao L, et al.
International Journal of Molecular Sciences, 20(8), 1858-1858 (2019)
Effect of mesenchymal stem cell transplantation on brain-derived neurotrophic factor expression in rats with Tourette syndrome
Liu X, et al.
Experimental and Therapeutic Medicine, 11(4), 1211-1216 (2016)
Xiumei Liu et al.
Experimental and therapeutic medicine, 11(4), 1211-1216 (2016-04-14)
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (MSC) transplantation on brain-derived neurotrophic factor (BDNF) expression in the striatum of Tourette syndrome (TS) rats. In addition, the possible mechanism of MSC
Shervin Pejhan et al.
Frontiers in cell and developmental biology, 8, 763-763 (2020-09-26)
Rett Syndrome (RTT) is a rare and progressive neurodevelopmental disorder that is caused by de novo mutations in the X-linked Methyl CpG binding protein 2 (MECP2) gene and is subjected to X-chromosome inactivation. RTT is commonly associated with neurological regression
Zuzana Paduchová et al.
Nutrients, 13(4) (2021-04-04)
In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD
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Could you please confirm if this kit is capable of recognizing both free and bound BDNF?
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