N0267

(±)-Nicotine

≥99% (TLC), liquid

• Tapasztalati képlet (Hill-képlet): C₁₀H₁₄N₂
• CAS-szám: 22083-74-5
• Molekulatömeg: 162.23
• Beilstein: 82108
• MDL-szám: MFCD00065370
• UNSPSC kód: 12352210
• eCl@ss: 39151701
• PubChem Substance ID: 24897418
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥99% (TLC)
• Forma: liquid
• optikai aktivitás: [α]25/D 0°(lit.)
• szín: yellow
• oldhatóság: ethanol: 50 mg/mL
• sűrűség: 1.02 g/mL at 25 °C (lit.)
• SMILES string: CN1CCCC1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
• Nemzetközi kémiai azonosító kulcs: SNICXCGAKADSCV-UHFFFAOYSA-N
• Géninformáció: human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) ; rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

Leírás

Alkalmazás

(±)-Nicotine has been used:

• as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
• as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
• as a test compound to study its effects on fibril formation

Biokémiai/fiziológiai hatások

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Prototype nicotinic acetylcholine receptor agonist.

Kiszerelés

The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.

Biztonsági adatok

• Piktogramok: GHS06,GHS05,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H310 + H330,H315,H318,H411
• Óvintézkedésre vonatkozó mondatok: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): 213.8 °F - closed cup
• Lobbanási pont (C): 101 °C - closed cup
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter