M6191

GW9662

>98% (HPLC)

• Szinonimák: 2-Chloro-5-nitro-N-phenylbenzamide
• Tapasztalati képlet (Hill-képlet): C₁₃H₉ClN₂O₃
• CAS-szám: 22978-25-2
• Molekulatömeg: 276.68
• MDL-szám: MFCD01215270
• UNSPSC kód: 51111800
• PubChem Substance ID: 24278560
• NACRES: NA.77

Tulajdonságok

• Teszt: >98% (HPLC)
• form: powder
• szín: white
• oldhatóság: DMSO: 26 mg/mL; H₂O: insoluble
• tárolási hőmérséklet: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccccc2
• InChI: 1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
• Nemzetközi kémiai azonosító kulcs: DNTSIBUQMRRYIU-UHFFFAOYSA-N
• Géninformáció: human ... PPARG(5468)

Leírás

Alkalmazás

GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.

Biokémiai/fiziológiai hatások

GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.

GW9662 is an irreversible PPARγ antagonist. GW9662 inhibits connective tissue growth factor and activation of CD36 by IL-4.

Tulajdonságok és előnyök

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Jogi információk

Sold for research purposes only, under agreement from Glaxo­Smith­Kline

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3