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M3445

Sigma-Aldrich

Magnolol

≥90% (HPLC), from plant

Szinonimák:

2,2′-Bichavicol, 5,5′-Diallyl-2,2′-biphenyldiol

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Összes fotó(2)

About This Item

Tapasztalati képlet (Hill-képlet):
C18H18O2
CAS-szám:
528-43-8
Molekulatömeg:
266.33
MDL-szám:
MFCD00016658
UNSPSC kód:
12352100
PubChem Substance ID:
24896843
NACRES:
NA.25

biológiai forrás

plant

Minőségi szint

200

Teszt

≥90% (HPLC)

oldhatóság

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

antibiotikus hatásspektrum

Gram-negative bacteria
Gram-positive bacteria
fungi

alkalmazás(ok)

metabolomics
vitamins, nutraceuticals, and natural products

Hatásmechanizmus

cell membrane | interferes

tárolási hőmérséklet

2-8°C

SMILES string

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

Nemzetközi kémiai azonosító kulcs

VVOAZFWZEDHOOU-UHFFFAOYSA-N

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Általános leírás

Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound.

Alkalmazás

Magnolol has been used:
  • to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model
  • to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay
  • to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains
  • in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies

Biokémiai/fiziológiai hatások

Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.
Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Figyelmeztetés

Danger

Figyelmeztető mondatok

H315,H318,H335,H411

Óvintézkedésre vonatkozó mondatok

P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310

Veszélyességi osztályok

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Célzott szervek

Respiratory system

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Egyéni védőeszköz

dust mask type N95 (US), Eyeshields, Gloves

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Jawad Behbehani et al.
Microbial pathogenesis, 113, 209-217 (2017-10-28)
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral
Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Jie Cheng et al.
International immunopharmacology, 59, 61-67 (2018-04-09)
Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant-like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the aim of this present study was
View All Related Papers

Cikkek

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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