L7260

Oleoyl-L-α-lysophosphatidic acid sodium salt

≥98%, solid

• Szinonimák: 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt, LPA sodium salt
• Tapasztalati képlet (Hill-képlet): C₂₁H₄₁O₇P · xNa⁺
• CAS-szám: 22556-62-3
• Molekulatömeg: 436.52 (free acid basis)
• MDL-szám: MFCD00133427
• UNSPSC kód: 12352211
• PubChem Substance ID: 24896456
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98%
• form: solid
• szín: white
• lipidtípus: phosphoglycerides
• tárolási hőmérséklet: −20°C
• SMILES string: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);;/b10-9+;;
• Nemzetközi kémiai azonosító kulcs: CHJOEWDRTPWOCY-TTWKNDKESA-N

Leírás

Általános leírás

Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.

Alkalmazás

Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:

• for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell line
• in RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assay
• in vitro luciferase assay and live-cell imaging

Biokémiai/fiziológiai hatások

Endogenous agonist for LPA₁ and LPA₂ receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

Tulajdonságok és előnyök

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vigyázat

Hygroscopic, photosensitive

Elkészítési megjegyzés

Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)