AB2203
Anti-CLOCK Antibody
serum, Chemicon®
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
antitest forma
serum
antitest terméktípus
primary antibodies
klón
polyclonal
faj reaktivitás
mouse, human, rat
gyártó/kereskedő neve
Chemicon®
technika/technikák
western blot: suitable
GenBank elérési szám
kiszállítva
wet ice
célzott transzláció utáni módosítás
unmodified
Géninformáció
mouse ... Clock(12753)
Általános leírás
Circadian Locomotor Output Cycles Kaput, or Clock is a gene which encodes proteins regulating circadian rhythm. This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like protein to activate transcription of mouse period 1.
Egyediség
Cat. # AB2203 recognizes CLOCK protein
Reactivity with other species has not been tested.
Alkalmazás
Anti-CLOCK Antibody is an antibody against CLOCK for use in WB.
Western Blot Analysis:
L6 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-CLOCK (1:500 dilution of this lot).
Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
L6 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-CLOCK (1:500 dilution of this lot).
Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Minőség
Routinely evaluated by western blot on L6 tissue lysate.
Cél megnevezése
Approx. 95 kDa
Analízis megjegyzés
Control
L6 Cell Lysate.
L6 Cell Lysate.
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Jogi információk
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
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Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
Testing null
Xiaoqin Liu et al.
PloS one, 7(11), e50602-e50602 (2012-11-29)
Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein products. In the mammalian
Yohei Kobayashi et al.
Neuron, 86(1), 264-275 (2015-03-25)
Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of
Mark A Naven et al.
Theranostics, 12(8), 3963-3976 (2022-06-07)
The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty in obtaining circadian time series human cartilage tissues. As
Arthur H Cheng et al.
Cell reports, 26(12), 3191-3202 (2019-03-21)
Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other transcription factors outside of the circadian TTFLs to the functionality of the SCN
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