H6036

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

powder, ≥98% (HPLC)

• Szinonimák: PPT
• Tapasztalati képlet (Hill-képlet): C₂₄H₂₂N₂O₃
• CAS-szám: 263717-53-9
• Molekulatömeg: 386.44
• MDL-szám: MFCD03453628
• UNSPSC kód: 51111800
• PubChem Substance ID: 24278470
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: white to tan
• oldhatóság: DMSO: soluble 20 mg/mL; H₂O: insoluble
• tárolási hőmérséklet: 2-8°C
• SMILES string: CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4
• InChI: 1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
• Nemzetközi kémiai azonosító kulcs: IOTXSIGGFRQYKW-UHFFFAOYSA-N
• Géninformáció: human ... ESR1(2099)

Leírás

Általános leírás

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Alkalmazás

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole has been used to cultivate differentiated adipocytes. It is also used in drug treatments and radioimmunoassay (RIA).

Biokémiai/fiziológiai hatások

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.

PPT is a specific estrogen receptor α (ERα) agonist.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)