5.31042

ICI 182,780

≥98% (HPLC), powder, GPR30 agonist, Calbiochem^®

• Szinonimák: Estrogen Receptor Antagonist, ICI 182,780, GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
• Tapasztalati képlet (Hill-képlet): C₃₂H₄₇F₅O₃S
• CAS-szám: 129453-61-8
• Molekulatömeg: 606.77
• MDL-szám: MFCD00903953
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Terméknév: Estrogen Receptor Antagonist, ICI 182,780,
• Teszt: ≥98% (HPLC)
• Minőségi szint: 100
• Forma: powder
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: white
• oldhatóság: DMSO: 100 mg/mL
• tárolási hőmérséklet: 2-8°C
• SMILES string: FC(F)(F)C(F)(F)CCC[S](=O)CCCCCCCCC[C@H]1[C@H]2[C@H]3[C@@]([C@H](CC3)O)(CC[C@@H]2c4c(cc(cc4)O)C1)C
• InChI: 1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
• Nemzetközi kémiai azonosító kulcs: VWUXBMIQPBEWFH-WCCTWKNTSA-N

Leírás

Általános leírás

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.



Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
ER

Secondary Target
GPR30

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Wakeling, A. E., et al. 1991. Cancer Res.51, 3867.
Dauvois, S., et al. 1993. J. Cell. Sci.106, 1377.
Howell, A., et al. 1995. The Lancet.8941, 29.
Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol.79, 209.

Jogi információk

Sold with the permission of AstraZeneca UK. Limited for research purposes only.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Figyelmeztető mondatok: H413
• Óvintézkedésre vonatkozó mondatok: P273 - P501
• Veszélyességi osztályok: Aquatic Chronic 4
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3