Összes fotó(1)
Fontos dokumentumok
G9152
Anti-Galactocerebroside antibody produced in rabbit
whole antiserum
Szinonimák:
Galactocerebroside Antibody, Galactocerebroside Antibody - Anti-Galactocerebroside antibody produced in rabbit
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
whole antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
tartalmaz
15 mM sodium azide
faj reaktivitás
human
technika/technikák
dot blot: 1:50 using galactocerebroside I and II
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... GALC(2581)
Általános leírás
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves.
This product is a pooled delipidized antiserum produced in rabbits by repeated injections of a mixture of galactocerebrosides I and II conjugated to keyhole limpet hemocyanin.
Egyediség
The antibody localizes oligodendroglia in cultured cells. It may be used for studying changes in the organization of oligodendroglial membrane sheets in culture. Specificity of the product is determined by dot blotting using galactocerebroside as the antigen.
Immunogen
Galactocerebrosides (GalC) I and II conjugated to KLH
Alkalmazás
Anti-Galactocerebroside antibody produced in rabbit has been used:
- for dot-blot immunoassay and western blot analysis of mouse brain homogenates
- as a primary antibody at a working dilution of 1:50 for immunostaining of muscle tissue of Rana pipiens frogs
- as a primary antibody at a working dilution of 1:500 in immunofluorescence and immunohistochemistry using primary human astroglia
Biokémiai/fiziológiai hatások
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves. Galactocerebroside is found in serum and cerebral spinal fluid of patients with demyelinating diseases like multiple sclerosis.
Galactocerebroside was shown to play an important role in the processes of normal development and myelination and is known to be an early marker of oligodendrocyte development.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
C A Dyer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 8(11), 4307-4318 (1988-11-01)
Antibodies to galactocerebroside (GalC) cause major changes in the organization of the membrane sheets elaborated by murine oligodendroglia in culture. Exposure of oligodendroglia to rabbit anti-GalC IgG for 15 min followed by fluoresceinated second antibodies results in patches of surface
D M Kokkinakis et al.
Neuro-oncology, 3(2), 99-112 (2001-04-12)
Glial tumors may originate from the malignant transformation of multipotent glial progenitor cells, but tools to study malignant transformation leading to gliomas are limited by the lack of biological systems that represent early stages of this disease in adult animals.
J W Prineas et al.
Laboratory investigation; a journal of technical methods and pathology, 61(5), 489-503 (1989-11-01)
Fresh lesions in the brain and spinal cord of patients with multiple sclerosis who died shortly after the onset of symptoms were examined immunocytochemically for myelin and oligodendrocyte antigens that are known to be sequentially expressed during normal development. Cells
Lead alters the developmental profile of the galactolipid metabolic enzymes in cultured oligodendrocyte lineage cells
Deng W and Poretz RD
Neurotoxicology, 22(4), 429-437 (2001)
J Georgiou et al.
Glia, 27(2), 101-109 (1999-07-27)
Perisynaptic Schwann cells (PSCs) envelop axonal terminals and are physiologically distinct from the nearby myelinating Schwann cells (MSCs), which surround the same innervating motor axons. PSCs have special functions at the neuromuscular synapse, where they detect and can modulate neurotransmitter
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