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Merck

F9512

Sigma-Aldrich

Anti-Human IgG (Fc specific)−FITC antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Szinonimák:

Anti Human IgG Fitc - Anti-Human IgG (Fc specific)-FITC antibody produced in goat, Anti Human Igg Fitc

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352203
NACRES:
NA.46

biológiai forrás

goat

Minőségi szint

konjugátum

FITC conjugate

antitest forma

affinity isolated antibody

antitest terméktípus

secondary antibodies

klón

polyclonal

Forma

buffered aqueous solution

tárolási körülmény

protect from light

technika/technikák

immunofluorescence: 1:64-1:128 using Hep2 cells

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Általános leírás

IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
Anti-Human IgG (Fc specific)-FITC antibody specifically recognizes Fc fragment of all human IgG subclasses. The conjugate shows no reactivity with human IgG Fab fragment, IgA, IgM and light chains and normal mouse or rat serum proteins. The antibody is purified by immunospecific purification and then conjugated to FITC.
Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. An immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein. IgG is usually found as a monomer. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4. About 70 percent of the total immunoglobulin consists of IgG. The antibody is isolated from goat anti-human IgG antiserum by immunospecific purification, which removes essentially all goat serum proteins, including immunoglobulins, which do not specifically bind to the Fc fragment of human IgG.

Egyediség

Binds human IgG; does not bind other human Igs.
Provides reduced background with mouse or rat samples

Immunogén

Purified human IgG Fc fragment

Alkalmazás

Anti-Human IgG (Fc specific)-FITC antibody produced in goat has been used in:
  • immunofluorescence
  • immunohistochemistry
  • surface labeling experiments

Biokémiai/fiziológiai hatások

Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense.

Egyéb megjegyzések

No cross-reaction with mouse and rat IgG.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

nwg


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Dokumentumtár megtekintése

Sebastian B Riese et al.
Journal of immunology (Baltimore, Md. : 1950), 192(4), 1862-1869 (2014-01-17)
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Roshan James et al.
Cancer medicine, 1(2), 114-127 (2013-01-24)
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Xiao-yun Liu et al.
mAbs, 4(1), 57-68 (2012-02-14)
An immunotoxin (IT) constructed with RFB4, a murine anti-CD22 monoclonal antibody, and the "deglycosylated" A chain of ricin has shown activity at safe doses in patients with non-Hodgkin lymphoma and in children with acute lymphoblastic leukemia. The dose limiting toxicity
Usha Bughani et al.
PloS one, 12(7), e0180088-e0180088 (2017-07-04)
CD6 is associated with T-cell modulation and is implicated in several autoimmune diseases. We previously demonstrated that Itolizumab, a CD6 domain 1 (CD6D1) specific humanized monoclonal antibody, inhibited the proliferation and cytokine production by T lymphocytes stimulated with anti-CD3 antibody
Towards translational ImmunoPET/MR imaging of invasive pulmonary aspergillosis: the humanised monoclonal antibody JF5 detects Aspergillus lung infections in vivo
Davies G, et al.
Theranostics, 7(14), 3398-3398 (2017)

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