F3385

Fetuin from fetal bovine serum

lyophilized powder, BioReagent, suitable for cell culture

• Szinonimák: Fetuin from fetal calf serum
• CAS-szám: 9014-81-7
• EC-szám: 232-762-7
• MDL-szám: MFCD00131055
• UNSPSC kód: 12352202
• NACRES: NA.75

Tulajdonságok

• termékcsalád: BioReagent
• Minőségi szint: 200
• Forma: lyophilized powder
• molekulatömeg: 48.4 kDa
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: ≤0.3% free N-acetylneuraminic acid
• oldhatóság: H₂O: 1 mg/mL
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

Fetuin from fetal bovine serum is a plasma glycoprotein. It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue.
A glycoprotein derived from FBS that is used as Fetuin has been used at a concentration of 500 mg/ml to supplement serum free F12 medium (along with insulin, transferrin and 2-mercaptoethanol) in culture of embryonal carcinoma cells.

Alkalmazás

Fetuin from fetal bovine serum has been used:

• as a substrate to determine neuraminidase activity
• to validate the specificity of sialidases
• to stabilize m-calpain

Biokémiai/fiziológiai hatások

Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism. Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases. Fetuin exhibits anti-inflammatory property.

Elkészítési megjegyzés

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)