D7000

Deoxycorticosterone acetate

• Szinonimák: 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate
• Tapasztalati képlet (Hill-képlet): C₂₃H₃₂O₄
• CAS-szám: 56-47-3
• Molekulatömeg: 372.50
• Beilstein: 2570798
• EC-szám: 200-275-9
• MDL-szám: MFCD00003660
• UNSPSC kód: 12352200
• PubChem Substance ID: 24894065
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• sterilitás: non-sterile
• Teszt: ≥98% (HPLC)
• Forma: powder
• oldhatóság: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• kiszállítva: ambient
• tárolási hőmérséklet: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• Nemzetközi kémiai azonosító kulcs: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Géninformáció: human ... NR3C2(4306)

Leírás

Általános leírás

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Alkalmazás

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)