C7698

Cycloheximide

from microbial, ≥94% (TLC)

• Szinonimák: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₃NO₄
• CAS-szám: 66-81-9
• Molekulatömeg: 281.35
• Beilstein: 88868
• EC-szám: 200-636-0
• MDL-szám: MFCD00082346
• UNSPSC kód: 12352111
• PubChem Substance ID: 24892981
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: microbial
• Minőségi szint: 200
• Teszt: ≥94% (TLC)
• Forma: powder
• szín: white to off-white
• oldhatóság: ethanol: soluble, clear to hazy
• antibiotikus hatásspektrum: fungi; yeast
• Hatásmechanizmus: protein synthesis | interferes
• tárolási hőmérséklet: 2-8°C
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Nemzetközi kémiai azonosító kulcs: YPHMISFOHDHNIV-FSZOTQKASA-N
• Géninformáció: human ... FKBP1A(2280) , PIN1(5300)

Leírás

Általános leírás

Cycloheximide, also known as Actidione, is a glutarimide antibiotic commonly derived from the bacterium Streptomyces griseus. It acts as a potent inhibitor of protein biosynthesis in eukaryotic cells by disrupting the translocation step during translation, effectively blocking translational elongation. In microbiology, it plays a crucial role as a selection agent for resistant strains of yeast and fungi, proving invaluable in controlled experimental environments.

In cell biology and biochemical research, Cycloheximide showcases a dual nature concerning Apoptosis Induction, inducing or inhibiting apoptosis depending on the cell type. Its rapid and reversible effects make it an ideal choice for studying cellular processes and determining protein half-life. Cycloheximide also finds extensive applications in biomedical research, where it inhibits protein synthesis in eukaryotic cells studied in vitro (outside of organisms) and its effects are rapidly reversed by simply removing it. This makes Cycloheximide a go-to choice for exploring cell biology, biomedical and biochemical research, offering precise control and versatility in experiments.

Alkalmazás

• In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
• It has been used to inhibit translation in mammalian cells.
• It has been used to suppress fungal growth.

Biokémiai/fiziológiai hatások

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Tulajdonságok és előnyök

• High-quality antibiotic suitable for multiple research applications
• Commonly used in Cell Biology and Biochemical applications

Tárolás és stabilitás

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.

Egyéb megjegyzések

For additional information on our range of Biochemicals, please complete this form.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Biztonsági adatok

• Piktogramok: GHS06,GHS08,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300,H341,H360D,H411
• Óvintézkedésre vonatkozó mondatok: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Veszélyességi osztályok: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges