C1988

Cycloheximide

Biotechnology Performance Certified

• Szinonimák: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₃NO₄
• CAS-szám: 66-81-9
• Molekulatömeg: 281.35
• Beilstein: 88868
• EC-szám: 200-636-0
• MDL-szám: MFCD00082346
• UNSPSC kód: 51102829
• PubChem Substance ID: 24892457
• NACRES: NA.85

Tulajdonságok

• grade: Biotechnology Performance Certified
• Minőségi szint: 200
• form: powder
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• oldhatóság: ethanol: 50 mg/mL
• antibiotikus hatásspektrum: fungi; yeast
• Hatásmechanizmus: protein synthesis | interferes
• tárolási hőmérséklet: 2-8°C
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Nemzetközi kémiai azonosító kulcs: YPHMISFOHDHNIV-FSZOTQKASA-N
• Géninformáció: human ... FKBP1A(2280) , PIN1(5300)

Leírás

Alkalmazás

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques and activate cumulus-free equine oocytes.

Biokémiai/fiziológiai hatások

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation. More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.

Egyéb megjegyzések

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Biztonsági adatok

• Piktogramok: GHS06,GHS08,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300,H341,H360D,H411
• Óvintézkedésre vonatkozó mondatok: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Veszélyességi osztályok: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges