Összes fotó(1)
Fontos dokumentumok
C5737
Monoclonal Anti-Caspase 3 antibody produced in mouse
clone 84803.111, purified immunoglobulin, lyophilized powder
Szinonimák:
Anti-Apopain, Anti-CPP32, Anti-Yama
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
mouse
Minőségi szint
konjugátum
unconjugated
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
84803.111, monoclonal
form
lyophilized powder
faj reaktivitás
human
technika/technikák
western blot: 1.0 μg/mL using human Jurkat cells
izotípus
IgG2b
UniProt elérési szám
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... CASP3(836)
Related Categories
Általános leírás
CASP3 (caspase 3) is a cysteine protease belonging to the caspase protein family, and is related to interleukin-1β-converting enzyme (ICE). It is the human homologue of Caenorhabditis elegans Ced-3 protein. This protein forms a key element of apoptosis.
Egyediség
Detects recombinant human precursor caspase 3 and the 18 kDa form produced during apoptosis.
Immunogen
recombinant 18 kDa subunit, amino acids 29-175, of human caspase 3.
Biokémiai/fiziológiai hatások
CASP3 (caspase 3) is an essential protein of apoptosis, which includes multiple death-inducing signals, and caspase 3 functions at the last steps of programmed cell death. This protein is shown to be expressed in esophageal squamous cell carcinoma (ESCC), and its down-regulation is related to increased malignancy and reduced overall survival. Its expression in metastatic lymph nodes (LN) might serve as a marker for poor survival prognosis in patients with resected ESCC and metastasis to LN. Studies in multiple cancers such as, gastric, colorectal, ovarian and cervical cancers show that aberrant expression of this gene is linked with cancer progression and aggressive behavior. It might have potential as a marker to determine the prognosis of the above cancers.
Fizikai forma
Lyophilized from a 0.2 μm filtered solution in 0.01 M phosphate buffered saline with 5% trehalose.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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javasolt
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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