Összes fotó(4)
Fontos dokumentumok
C1057
Butyrylcholinesterase from equine serum
lyophilized powder, ≥900 units/mg protein
Szinonimák:
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)
About This Item
Javasolt termékek
Forma
lyophilized powder
Minőségi szint
specifikus aktivitás
≥900 units/mg protein
molekulatömeg
tetramer 440 kDa
összetétel
Protein, ≥10%
oldhatóság
H2O: soluble 10 mg/mL
alkalmazás(ok)
diagnostic assay manufacturing
tárolási hőmérséklet
−20°C
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Alkalmazás
Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents. Cholinesterases have also been investigated for their role in Alzheimer′s disease.
Biokémiai/fiziológiai hatások
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Egység definíció
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
Fizikai forma
Highly purified; contains buffer salts
Analízis megjegyzés
Protein determined by biuret
Figyelmeztetés
Danger
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Resp. Sens. 1
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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