B8936

Betulinic acid

≥98% (HPLC)

• Szinonimák: 3β-Hydroxy-20(29)-lupaene-28-oic acid, Lupatic acid, Mairin
• Tapasztalati képlet (Hill-képlet): C₃₀H₄₈O₃
• CAS-szám: 472-15-1
• Molekulatömeg: 456.70
• EC-szám: 207-448-8
• MDL-szám: MFCD00009619
• UNSPSC kód: 12352205
• PubChem Substance ID: 329773146
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: powder
• mp: 295-298 °C (dec.) (lit.)
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: 2-8°C
• SMILES string: CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
• InChI: 1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
• Nemzetközi kémiai azonosító kulcs: QGJZLNKBHJESQX-FZFNOLFKSA-N

Leírás

Általános leírás

Betulinic acid (BetA) is a natural product mostly sourced from the birch tree (Betula spp.). This pentacyclic lupanetype triterpenoid is also associated with other species such as Syzygium spp., Diospyros spp., Ziziphus spp., and Paeonia spp..

Alkalmazás

Betulinic acid (BetA) has been used:

• to test its effects as an antiviral agent against Dengue virus (DENV)
• as a sterol regulatory element-binding protein (SREBP) inhibitor to repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells
• as a treatment to test its anti-tumor properties for cell viability and apoptotic cell death assays in multiple myeloma models

Biokémiai/fiziológiai hatások

Betulinic acid displays many biological and pharmacological properties such as anticancer, anti-inflammatory, anti-bacterial, anti-human immunodeficiency virus (HIV), and anti-malarial properties.

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable