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Merck
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Fontos dokumentumok

B0806

Sigma-Aldrich

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit

enhanced validation

affinity isolated antibody, buffered aqueous solution

Szinonimák:

Anti-β-Site APP Cleaving Enzyme

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)

About This Item

MDL-szám:
MFCD03454775
UNSPSC kód:
12352203
NACRES:
NA.43

biológiai forrás

rabbit

Minőségi szint

200

konjugátum

unconjugated

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

form

buffered aqueous solution

molekulatömeg

antigen 70 kDa

faj reaktivitás

human

fejlettebb validálás

recombinant expression
Learn more about Antibody Enhanced Validation

technika/technikák

microarray: suitable
western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1

UniProt elérési szám

P56817

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... BACE1(23621)

Related Categories

Általános leírás

BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) is known as β-secretase. BACE-1 is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. It constitutes the predominant β-secretase activity in human brain tissue.

Immunogen

synthetic peptide corresponding to the C-terminus of human BACE-1 (amino acids 485-501).

Alkalmazás

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit has been used in western blotting.

Biokémiai/fiziológiai hatások

Overexpression of β-site APP cleaving enzyme (BACE-1) leads to increased β-secretase activity while displaying appropriate cleavage site specificity for amyloid precursor protein (APP).

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

nwg

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

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Amanda Gonzales et al.
Journal of neuroscience methods, 202(1), 70-76 (2011-09-06)
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