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171610

Sigma-Aldrich

Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb

liquid, Calbiochem®

Szinonimák:

Anti-0443, Anti-APP-CT20

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About This Item

UNSPSC kód:
12352203
NACRES:
NA.43

biológiai forrás

rabbit

Minőségi szint

100

antitest forma

serum

antitest terméktípus

primary antibodies

klón

polyclonal

form

liquid

faj reaktivitás

human

gyártó/kereskedő neve

Calbiochem®

tárolási körülmény

OK to freeze

izotípus

IgG

kiszállítva

ambient

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Általános leírás

Anti-Amyloid Precursor Protein, C-Terminal (751-770), rabbit polyclonal, recognizes full-length APP and C-terminal soluble products CTFα, β, and γ. It is validated for WB, IF, IHC, and IP.
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
  • Antibody Target Gene Symbol: APP
  • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
  • Entrez Gene Name: amyloid beta (A4) precursor protein
  • Hu Entrez ID: 351 (Related Antibodies: PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
  • Mu Entrez ID: 11820
  • Rat Entrez ID: 54226

    • Immunogen

    Human
    a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH

    Alkalmazás

    Immunoblotting (1:5000-1:20,000)

    Immunofluorescence (1:1000)

    Immunohistochemistry (1:1000)

    Immunoprecipitation (1:1000)

    Figyelmeztetés

    Toxicity: Standard Handling (A)

    Feloldás

    Following initial thaw, aliquot and freeze (-20°C).

    Egyéb megjegyzések

    Pinnix, I., et al. 2001. J. Biol. Chem.276, 481.
    Variables associated with assay conditions will dictate the proper working dilution.

    Jogi információk

    Purchase of this material is for research use only. Users are invited to request a license from Mayo prior to using the 0433 antibody or any derivatives for clinical diagnostic or therapeutic purposes. For license information, please contact: Mayo Medical Ventures, Office of Technology Commercialization (507) 284-8878, 200 First Street SW, Rochester, MN 55905-001.
    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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    Tárolási osztály kódja

    10 - Combustible liquids

    WGK

    WGK 1

    Lobbanási pont (F)

    Not applicable

    Lobbanási pont (C)

    Not applicable

    Analitikai tanúsítványok (COA)

    Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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    Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

    Dokumentumtár megtekintése

    Inderjeet Saluja et al.
    Neurobiology of disease, 36(1), 162-168 (2009-07-28)
    The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9
    Ramon Velazquez et al.
    Aging cell, 18(6), e13037-e13037 (2019-09-29)
    Currently, there are no effective therapies to ameliorate the pathological progression of Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to AD. Notably, dietary nutrients are suggested to play a key role in mediating mechanisms associated with brain
    Ramon Velazquez et al.
    Molecular psychiatry, 25(10), 2620-2629 (2019-01-10)
    The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine (Hcy) levels double the risk of developing AD.
    Giselle P Lim et al.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(12), 3032-3040 (2005-03-25)
    Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). DHA levels are lower in serum and brains of AD patients, which could result
    Xiqian Lan et al.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7(2), 412-423 (2011-08-10)
    Combined antiretroviral therapy (ART) tremendously improved the lifespan and symptoms associated with AIDS-defining illness in affected individuals. However, chronic ART-treated patients frequently develop age-dependent complications, including dementia, diabetes, and hyperlipidemia: all risk factors of Alzheimer's disease. Importantly, the effect of
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