Összes fotó(1)
Fontos dokumentumok
70485
Naphthol AS-E phosphate
suitable for histology
Szinonimák:
KG-501
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C17H13ClNO5P
CAS-szám:
Molekulatömeg:
377.72
Beilstein:
6664478
EC-szám:
MDL-szám:
UNSPSC kód:
12352204
PubChem Substance ID:
NACRES:
NA.83
Javasolt termékek
Teszt
≥80% (HPLC)
Minőségi szint
Forma
powder
alkalmazás(ok)
histology
tárolási hőmérséklet
2-8°C
SMILES string
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
Nemzetközi kémiai azonosító kulcs
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Related Categories
Alkalmazás
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biokémiai/fiziológiai hatások
Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.
Egyéb megjegyzések
Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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