27840

Corticosterone

≥98.5% (HPLC)

• Szinonimák: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Tapasztalati képlet (Hill-képlet): C₂₁H₃₀O₄
• CAS-szám: 50-22-6
• Molekulatömeg: 346.46
• Beilstein: 2339601
• EC-szám: 200-019-6
• MDL-szám: MFCD00037715
• UNSPSC kód: 12352211
• PubChem Substance ID: 57648276
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: synthetic
• Minőségi szint: 200
• Teszt: ≥98.5% (HPLC)
• form: powder or crystals
• optikai aktivitás: [α]20/D +223±3°, c = 1% in ethanol
• mp: 179-183 °C (lit.); 179-183 °C
• funkcionális csoport: ketone
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Nemzetközi kémiai azonosító kulcs: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Géninformáció: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Leírás

Általános leírás

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Alkalmazás

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Biokémiai/fiziológiai hatások

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Kiszerelés

Bottomless glass bottle. Contents are inside inserted fused cone.

Elkészítési megjegyzés

Corticosterone is soluble in chloroform and ethanol.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves