C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Szinonimák: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Tapasztalati képlet (Hill-képlet): C₂₁H₃₀O₄
• CAS-szám: 50-22-6
• Molekulatömeg: 346.46
• Beilstein: 2339601
• EC-szám: 200-019-6
• MDL-szám: MFCD00037715
• UNSPSC kód: 51111800
• PubChem Substance ID: 24278302
• NACRES: NA.77

Tulajdonságok

• Terméknév: Corticosterone, ≥92%
• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• Teszt: ≥92%
• Forma: powder
• mp: 179-183 °C (lit.)
• oldhatóság: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• kiszállítva: ambient
• tárolási hőmérséklet: room temp
• SMILES string: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Nemzetközi kémiai azonosító kulcs: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Géninformáció: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Leírás

Alkalmazás

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Biokémiai/fiziológiai hatások

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves