Összes fotó(1)
Fontos dokumentumok
PHR1098
N-Acetyl-L-cysteine
Pharmaceutical Secondary Standard; Certified Reference Material
Szinonimák:
LNAC, NAC
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Lineáris képlet:
HSCH2CH(NHCOCH3)CO2H
CAS-szám:
Molekulatömeg:
163.19
Beilstein:
1724426
EC-szám:
MDL-szám:
UNSPSC kód:
41116107
PubChem Substance ID:
NACRES:
NA.24
Javasolt termékek
grade
certified reference material
pharmaceutical secondary standard
Minőségi szint
Ügynökség
traceable to BP 907
traceable to Ph. Eur. A0150000
traceable to USP 1009005
API-család
acetylcysteine
Analitikai műbizonylat
current certificate can be downloaded
tárolási körülmény
protect from light
technika/technikák
HPLC: suitable
gas chromatography (GC): suitable
mp
106-108 °C (lit.)
alkalmazás(ok)
pharmaceutical (small molecule)
Formátum
neat
tárolási hőmérséklet
2-8°C
SMILES string
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
Nemzetközi kémiai azonosító kulcs
PWKSKIMOESPYIA-BYPYZUCNSA-N
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Általános leírás
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine. It finds use in clinical applications as a mucolytic agent typically administered by inhalation.
N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine. It finds use in clinical applications as a mucolytic agent typically administered by inhalation.
Alkalmazás
N-Acetyl-L-cysteine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography-mass spectrometry (LC-MS) and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biokémiai/fiziológiai hatások
Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Analízis megjegyzés
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Egyéb megjegyzések
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Lábjegyzet
To see an example of a Certificate of Analysis for this material enter LRAC0297in the slot below. This is an example certificate only and may not be the lot that you receive.
Javasolt termékek
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
kapcsolódó termék
Product No.
Leírás
Árazás
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Eye Irrit. 2
Tárolási osztály kódja
13 - Non Combustible Solids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Az ügyfelek ezeket is megtekintették
Spectrophotometric determination of N-acetyl-L-cysteine and N-(2-mercaptopropionyl)-glycine in pharmaceutical preparations.
Kukoc-Modun L and Radic N
International Journal of Analytical Chemistry, 2011(1-2), 191-199 (2011)
Pharmacokinetics of N-acetylcysteine in man.
Borgstrom L, et al.
European Journal of Clinical Pharmacology, 31(2), 217-222 (1986)
Quantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by liquid chromatography-UV detection-mass spectrometry.
Toussaint B,
Journal of Chromatography A, 896(1-2), 191-199 (2000)
Anna M Sadowska
Therapeutic advances in respiratory disease, 6(3), 127-135 (2012-03-01)
To develop an efficient therapy for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) has been tested as a medication that can suppress various pathogenic processes in this disease. NAC is a thiol compound, which provides sulfhydryl groups. NAC can act
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
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