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A8456

Sigma-Aldrich

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

≥97.0% (HPLC)

Szinonimák:

AEBSF

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

Tapasztalati képlet (Hill-képlet):
C8H10FNO2S · HCl
CAS-szám:
30827-99-7
Molekulatömeg:
239.69
Beilstein:
7604627
MDL-szám:
MFCD00132962
UNSPSC kód:
12352202
PubChem Substance ID:
24278240
NACRES:
NA.77

biológiai forrás

synthetic (organic)

Minőségi szint

300

Teszt

≥97.0% (HPLC)

form

powder

mp

183-191  °C

oldhatóság

H2O: 50 mg/mL

tárolási hőmérséklet

−20°C

SMILES string

FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

Nemzetközi kémiai azonosító kulcs

WRDABNWSWOHGMS-UHFFFAOYSA-N

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Általános leírás

stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.

Alkalmazás

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) has been used:
  • as a protease inhibitor in plasma samples to prevent acylated ghrelin (AG) degradation
  • as a snake venom serine proteinase (SVSP) inhibitor in SVSP inhibition or AEBSF assay to test the involvement of SVSPs on the fibrinogen-clotting activity
  • as a component in NP-40 lysis buffer to resuspend cell pellets for preparing cell lysates

Recommended concentrations for use are 0.1-1 mM.

Biokémiai/fiziológiai hatások

AEBSF can inhibit acetylcholinesterase (AChE).
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) is an irreversible serine protease inhibitor. Inhibition constants are similar to those of phenylmethanesulfonyl fluoride (PMSF) and diisopropylfluorophosphate (DFP). AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein, and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water, and improved stability in aqueous solutions. AEBSF can be used in cell culture in concentrations of up to 0.25 mM.

Piktogramok

Corrosion
GHS05

Figyelmeztetés

Danger

Figyelmeztető mondatok

H314

Veszélyességi osztályok

Eye Dam. 1 - Skin Corr. 1A

Tárolási osztály kódja

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

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Analitikai tanúsítványok (COA)

Lot/Batch Number
0000389739
0000389740
0000359853
0000139495
069M4058V

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Dokumentumtár megtekintése

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Biochimica et biophysica acta, 1842(9), 1556-1566 (2014-06-03)
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ReadyShield® phosphatase and protease inhibitor cocktail FAQ for sample protection in a variety of cell types and tissue extracts, including mammalian, plant, and microbial samples. Our ReadyShield® Protease Inhibitor Cocktail is a non-freezing solution that contains inhibitors with a broad specificity for serine, cysteine, acid proteases and aminopeptidases.

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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