21186

Calcium ionophore III

Selectophore^™, function tested

• Szinonimák: Calcium Ionophore A23187, Antibiotic A 23187, Calimycin
• Tapasztalati képlet (Hill-képlet): C₂₉H₃₇N₃O₆
• CAS-szám: 52665-69-7
• Molekulatömeg: 523.62
• Beilstein: 1096801
• EC-szám: 258-084-1
• MDL-szám: MFCD00151202
• UNSPSC kód: 26111700
• PubChem Substance ID: 329752113
• NACRES: NB.61

Tulajdonságok

• grade: for ion-selective electrodes
• Minőségi szint: 200
• termékcsalád: Selectophore^™
• form: solid
• minőség: function tested
• antibiotikus hatásspektrum: Gram-positive bacteria; fungi
• Hatásmechanizmus: cell membrane | interferes
• tárolási hőmérséklet: 2-8°C
• SMILES string: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• Nemzetközi kémiai azonosító kulcs: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Leírás

Általános leírás

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Alkalmazás

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Kiszerelés

Bottomless glass bottle. Contents are inside inserted fused cone.

Egyéb megjegyzések

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Jogi információk

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves