AB4340
Anti-Zscan4 Antibody
from rabbit, purified by affinity chromatography
Szinonimák:
Zinc finger and SCAN domain containing protein 4C
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
100 μG
148 000,00 Ft
Összes fotó(4)
Méret kiválasztása
Nézet módosítása
100 μG
148 000,00 Ft
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
antitest forma
affinity isolated antibody
antitest terméktípus
primary antibodies
klón
polyclonal
tisztítva
affinity chromatography
faj reaktivitás
mouse
technika/technikák
immunoprecipitation (IP): suitable
western blot: suitable
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
célzott transzláció utáni módosítás
unmodified
Általános leírás
Zinc finger and SCAN domain containing protein 4C (UniProt: Q80VJ6) is encoded by the Zscan4c (also known as Gm397) gene (Gene ID: 245109) in mouse. Zscan4 is an embryonic stem (ES) cell-specific transcription factor required to regulate pluripotency, facilitate telomere elongation, and defy cellular senescence. It is expressed during zygotic genome activation in mouse two-cell embryos. It protects embryos from DNA damage by stabilizing the B-DNA form of microsatellite repeat DNA. It binds to the TGCACAC motif in CA/TG microsatellite repeats and regulates telomere elongation to maintain genomic stability and acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) in undifferentiated ES cells. Dysfunction of Zscan4 during development or in mESCs leads to implantation failure, telomere maintenance defects, and chromosomal rearrangements. (Ref.: Srinivasan, R., et al., (2020), Sci. Adv., 6, eaaz9115)
Immunogén
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of mouse Zscan4. The immunogen sequence is conserved between Zcsan4 family proteins (Zscan4b, Zscan4C, Zscan4d and Zscan4f).
Alkalmazás
Anti-Zscan4, Cat. No. AB4340, is a rabbit polyclonal antibody that detects Zscan4 and is tested for use in Western Blotting.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Minőség
Evaluated by Western Blotting in mouse embryonic stem cell (mESCs) lysate. Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Zscan4 in mouse embryonic stem cell (mESCs) lysate.
Cél megnevezése
Target molecular weight ~ 60 kDa observed; 60.0 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Fizikai forma
Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Tárolás és stabilitás
Recommended storage: +2°C to +8°C.
Analízis megjegyzés
Control
Embryonic Stem Cell lysates
Embryonic Stem Cell lysates
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Lei Yang et al.
EMBO reports, 21(9), e50054-e50054 (2020-07-28)
Cloned animals generated by somatic cell nuclear transfer (SCNT) have been reported for many years; however, SCNT is extremely inefficient, and zygotic genome activation (ZGA) is required for SCNT-mediated somatic cell reprogramming. To identify candidate factors that facilitate ZGA in
Role of Tet proteins in enhancer activity and telomere elongation.
Lu, F; Liu, Y; Jiang, L; Yamaguchi, S; Zhang, Y
Genes & Development null
Oncostatin M Maintains Naïve Pluripotency of mESCs by Tetraploid Embryo Complementation (TEC) Assay.
Xiaoying Ye et al.
Frontiers in cell and developmental biology, 9, 675411-675411 (2021-06-15)
It has been well established that leukemia inhibitory factor (LIF) is essential for maintaining naïve pluripotency of embryonic stem cells (ESCs). Oncostatin M (OSM) is a member of the IL-6 family of cytokines which share gp130 as a receptor subunit
Yuqing Zhu et al.
Stem cell reports, 16(11), 2659-2673 (2021-10-09)
Mouse embryonic stem cells (ESCs) show cell-to-cell heterogeneity. A small number of two-cell-like cells (2CLCs) marked by endogenous retrovirus activation emerge spontaneously. The 2CLCs are unstable and they are prone to transiting back to the pluripotent state without extrinsic stimulus.
Ane Iturbide et al.
Nature structural & molecular biology, 28(6), 521-532 (2021-05-29)
Totipotent cells hold enormous potential for regenerative medicine. Thus, the development of cellular models recapitulating totipotent-like features is of paramount importance. Cells resembling the totipotent cells of early embryos arise spontaneously in mouse embryonic stem (ES) cell cultures. Such '2-cell-like-cells'
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