869006-M

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

• Szinonimák: Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
• CAS-szám: 9002-71-5
• MDL-szám: MFCD00867077
• UNSPSC kód: 12352202
• NACRES: NA.32
• biológiai forrás: human pituitary glands
• Forma: lyophilized solid
• Teszt: ≥95% (weight)

Tulajdonságok

• biológiai forrás: human pituitary glands
• Minőségi szint: 100
• sterilitás: non-sterile
• Teszt: ≥95% (weight)
• Forma: lyophilized solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• technika/technikák: enzyme immunoassay: suitable
• szennyeződések: ≤0.1% hPRL (weight); ≤0.2% hGH, hFSH (weight); ≤0.3% hLH (weight)
• oldhatóság: 0.05 M PBS: 1 mg/mL
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... TSHB(7252)

Leírás

Általános leírás

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

Biokémiai/fiziológiai hatások

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

Figyelmeztetés

Toxicity: Standard Handling (A)

Egység definíció

1mg/ml in 0.05M PBS

Elkészítési megjegyzés

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable