475886

N^G-Monomethyl-L-arginine, Monoacetate Salt

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.

• Szinonimák: N^G-Monomethyl-L-arginine, Monoacetate Salt, N ^ω-Me-L-Arg, N ^G-Me-L-Arg, AcOH, L-NMMA, N^ω-Me-L-Arg, N^G-Me-L-Arg, AcOH, L-NMMA
• Tapasztalati képlet (Hill-képlet): C₇H₁₆N₄O₂ · xC₂H₄O₂
• CAS-szám: 53308-83-1
• Molekulatömeg: 188.23 (free base basis)
• MDL-szám: MFCD00069311
• UNSPSC kód: 12352209
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥99% (HPLC); ≥99% (TLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; desiccated (hygroscopic)
• szín: white
• oldhatóság: water: 50 mg/mL; methanol: soluble
• kiszállítva: ambient
• tárolási hőmérséklet: 10-30°C
• SMILES string: [N+H2]=C(NCCC[C@H](N)C(=O)O)NC.[O-]C(=O)C
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• Nemzetközi kémiai azonosító kulcs: IKPNWIGTWUZCKM-JEDNCBNOSA-N

Leírás

Általános leírás

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS; K_i = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

L-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (K_i = 650 nM for nNOS; K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
eNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.

Egyéb megjegyzések

Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys.320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun.158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA85, 8664.
Hibbs, J.B., et al. 1987. Science237, 473.
Palmer, R.M.J., et al. 1987. Nature327, 524.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable