215921

Chlorpromazine, Hydrochloride

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

• Szinonimák: Chlorpromazine, Hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₇H₁₉ClN₂S · xHCl
• CAS-szám: 69-09-0
• Molekulatömeg: 318.86 (free base basis)
• MDL-szám: MFCD00012654
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥99% (HPLC)
• Forma: crystalline solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; desiccated (hygroscopic)
• szín: off-white
• oldhatóság: methanol: 10 mg/mL; water: 50 mg/mL
• anion nyomok: sulfate (SO₄^2-): ≤0.05%
• kation nyomok: Fe: ≤0.001%; heavy metals: ≤0.002%
• kiszállítva: ambient
• tárolási hőmérséklet: 10-30°C
• SMILES string: S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• Nemzetközi kémiai azonosító kulcs: FBSMERQALIEGJT-UHFFFAOYSA-N

Leírás

Általános leírás

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Biokémiai/fiziológiai hatások

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Figyelmeztetés

Toxicity: Toxic (F)

Feloldás

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Egyéb megjegyzések

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS06
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H330
• Óvintézkedésre vonatkozó mondatok: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• Veszélyességi osztályok: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable