203389
Blebbistatin, Racemic
≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®
Szinonimák:
InSolutionBlebbistatin, Racemic
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C18H16N2O2
Molekulatömeg:
292.33
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
product name
Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II
Minőségi szint
Teszt
≥97% (HPLC)
form
liquid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
desiccated (hygroscopic)
protect from light
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Általános leírás
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
ATPase
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets
Kiszerelés
Packaged under inert gas
Figyelmeztetés
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Fizikai forma
A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Feloldás
Following initial thaw, aliquot and freeze (-20°C).
Egyéb megjegyzések
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Lobbanási pont (F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Lobbanási pont (C)
87 °C - closed cup - (Dimethylsulfoxide)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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