Összes fotó(1)
Fontos dokumentumok
M-080
Methylmalonic acid solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
grade
certified reference material
Minőségi szint
form
liquid
Jellemzők
Snap-N-Spike®/Snap-N-Shoot®
kiszerelés
ampule of 1 mL
gyártó/kereskedő neve
Cerilliant®
koncentráció
1.0 mg/mL in acetonitrile
technika/technikák
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
alkalmazás(ok)
clinical testing
pharmaceutical (small molecule)
format
single component solution
tárolási hőmérséklet
−20°C
SMILES string
CC(C(O)=O)C(O)=O
InChI
1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
Nemzetközi kémiai azonosító kulcs
ZIYVHBGGAOATLY-UHFFFAOYSA-N
Általános leírás
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution® is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
Alkalmazás
- Organic acid analysis for metabolic profiling: Research highlighted the integration of soil microbiota and metabolome, where methylmalonic acid was part of the metabolic profiling, revealing insights into how controlled release fertilizer impacts sugarcane growth, emphasizing the compound′s role in agricultural biotechnology (Yuan et al., 2023).
- Vitamin B12 deficiency research: Methylmalonic acid was featured in research on the cellular mechanisms affecting the MAFB/NOTCH3 axis in osteosarcoma, where its levels could potentially reflect perturbations relevant to vitamin B12 deficiency, aiding in better understanding of disease progression (Zhang et al., 2024).
- Methylmalonic acid standard for mass spectrometry analysis: The analysis of soybean root systems under varying nutrient conditions included methylmalonic acid as a standard in mass spectrometry to better understand nutrient uptake mechanisms, showcasing its utility in plant physiology and biochemistry studies (Qin et al., 2023).
Jogi információk
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
kapcsolódó termék
Product No.
Leírás
Árazás
Figyelmeztetés
Danger
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Tárolási osztály kódja
3 - Flammable liquids
WGK
WGK 2
Lobbanási pont (F)
35.6 °F - closed cup
Lobbanási pont (C)
2 °C - closed cup
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az ügyfelek ezeket is megtekintették
Wolfgang Herrmann et al.
European journal of clinical investigation, 43(3), 231-237 (2013-01-22)
There is an urgent need for proper utilization of laboratory markers to diagnose vitamin B12 deficiency that should reduce false negative cases. We worked out a diagnostic algorithm that provides a two-step detection of vitamin B12 deficiency using holotranscobalamin as
Marilyn H Hill et al.
The Journal of nutrition, 143(2), 142-147 (2012-12-14)
Plasma vitamin B-12 is the most commonly used biomarker of vitamin B-12 status, but the predictive value for low vitamin B-12 status is poor. The urinary methylmalonic acid (uMMA) concentration has potential as a functional biomarker of vitamin B-12 status
Bailey A Reindl et al.
Pediatrics, 130(5), e1363-e1368 (2012-10-17)
Within a 7-month period at our institution, newborn screening by tandem mass spectrometry revealed 10 cases with elevated levels of malonylcarnitine, which suggested malonic aciduria. Malonic aciduria is a rare autosomal recessive inborn error of metabolism. Confirmatory testing yielded normal
Sabina Lutz et al.
American journal of veterinary research, 73(8), 1194-1199 (2012-08-02)
To determine reference ranges for serum cobalamin (Cbl), urine methylmalonic acid (uMMA), and plasma total homocysteine (tHcys) concentrations and to compare values for healthy control dogs with values for Border Collies (BCs), a breed in which hereditary cobalamin deficiency has
Carolyn M Gallagher et al.
The Science of the total environment, 442, 48-55 (2012-11-28)
Children are susceptible to mercury toxicity, and mercury has immunomodulatory effects. Lower folate and B-12, and higher homocysteine may represent susceptibility cofactors. A large proportion of variability in rubella immune response is attributable to environmental factors. This study aimed to
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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