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Merck
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E-068

Supelco

Everolimus solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C53H83NO14
CAS-szám:
159351-69-6
Molekulatömeg:
958.22
MDL-szám:
MFCD00929329
UNSPSC kód:
41116107
PubChem Substance ID:
329798983
NACRES:
NA.24

grade

certified reference material

Minőségi szint

300

form

liquid

Jellemzők

(Snap-N-Spike®)

kiszerelés

ampule of 1 mL

gyártó/kereskedő neve

Cerilliant®

koncentráció

1.0 mg/mL in acetonitrile

technika/technikák

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

alkalmazás(ok)

clinical testing

format

single component solution

kiszállítva

dry ice

tárolási hőmérséklet

−70°C

InChI

1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

Nemzetközi kémiai azonosító kulcs

HKVAMNSJSFKALM-GKUWKFKPSA-N

Géninformáció

human ... FKBP1A(2280)

Related Categories

Általános leírás

Everolimus, sold under trade names including Zortress®, Certican, and Afinitor®, is an immunosuppressant drug used to prevent rejection of organ transplants and to treat renal cell cancer and other tumors. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of everolimus in patient whole blood samples by LC-MS/MS.

Alkalmazás


  • Everolimus as a therapy for hepatoblastoma: Research demonstrates that Everolimus can induce autophagy-dependent ferroptosis in hepatoblastoma cells, highlighting its potential as a therapeutic agent in oncology research. This study provides insight into the mechanisms by which Everolimus can be utilized to target cancer cells through cell death pathways (Huang et al., 2024).

  • Understanding oral mucosal injuries from mTOR inhibitors: A new hypothesis posits that oral mucosal injuries associated with mTOR inhibitors like Everolimus result from disruptions in cellular stress and apoptotic pathways. This study underscores the importance of understanding side effects in the context of targeted therapy for conditions such as cancers and immunosuppression (Sonis and Villa, 2023).

  • Micellar formulation of Everolimus for neurological disorders: A stable micellar formulation of Everolimus (RAD001) has been developed for intracerebroventricular delivery, aimed at treating Alzheimer′s Disease and other neurological disorders. This formulation allows for direct brain administration, potentially enhancing the drug′s efficacy and safety profile (Gianessi et al., 2023).

  • Pharmacokinetics in epilepsy treatment: The population pharmacokinetics of Everolimus were studied in patients with seizures associated with focal cortical dysplasia. This research aids in understanding the drug′s behavior in a specific neurological context, providing a foundation for dosing adjustments and therapeutic monitoring (Park et al., 2023).

Jogi információk

Afinitor is a registered trademark of Novartis AG
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Zortress is a registered trademark of Novartis AG

Piktogramok

FlameExclamation mark
GHS02,GHS07

Figyelmeztetés

Danger

Figyelmeztető mondatok

H225,H302 + H312 + H332,H319

Veszélyességi osztályok

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Tárolási osztály kódja

3 - Flammable liquids

WGK

WGK 2

Lobbanási pont (F)

35.6 °F - closed cup

Lobbanási pont (C)

2.0 °C - closed cup

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

L M Neri et al.
Leukemia, 28(4), 739-748 (2013-07-31)
B-precursor acute lymphoblastic leukemia (B-pre ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. The prognosis of B-pre ALL has improved in pediatric patients, but the outcome is much less successful in adults. Constitutive activation of
Catherine Lombard-Bohas et al.
Bulletin du cancer, 101(2), 175-183 (2014-02-22)
Medical management of pancreatic neuroendocrine tumors has recently been improved by new molecules of which the mTOR inhibitor everolimus. If digestive neuroendocrine tumors are rare, the incidence is in constant increase and the prevalence in digestive cancers put them right
Ian T Meredith et al.
The American journal of cardiology, 113(7), 1117-1123 (2014-02-18)
In the randomized PLATINUM trial, the PROMUS Element platinum-chromium everolimus-eluting stent (PtCr-EES; Boston Scientific, Natick, Massachusetts) was noninferior to the XIENCE V cobalt-chromium everolimus-eluting stent (CoCr-EES; Boston Scientific and Abbott Vascular, Santa Clara, California) for the primary end point of
Hirohiko Yasui et al.
Cancer letters, 347(1), 114-122 (2014-02-05)
We examined efficacy of the mTOR inhibitor RAD001 to seek novel therapies for synovial sarcoma (SS). Although RAD001 had significant anti-tumor effects, its sensitivity differed among cell lines. Phospho-receptor tyrosine kinase (RTK) array analyses revealed c-MET phosphorylation in highly mTOR
Michael Cardamone et al.
The Journal of pediatrics, 164(5), 1195-1200 (2014-02-13)
To evaluate the efficacy and side effects of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with tuberous sclerosis complex (TSC) and intractable epilepsy or subependymal giant cell astrocytoma (SEGA). Single-center series of 13 children and adolescents
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