QBD10551

MAL-dPEG^®₄-TFP ester

• Szinonimák: Polyethylene glycol
• Tapasztalati képlet (Hill-képlet): C₂₄H₂₈F₄N₂O₉
• Molekulatömeg: 564.48
• MDL-szám: MFCD28505515
• UNSPSC kód: 12352108
• PubChem Substance ID: 329823940
• NACRES: NA.22

Tulajdonságok

• Teszt: >90%
• form: solid or viscous liquid
• reakcióalkalmasság: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• funkcionális csoport: ester; maleimide
• polimer felépítés: shape: linear; functionality: heterobifunctional
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O

Leírás

Tulajdonságok és előnyök

MAL-dPEG^®₄-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG^® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Jogi információk

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable