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P2139

Sigma-Aldrich

Poly(ethylene glycol)

average MN 8,000, hydroxyl

Szinonimák:

Polyethylene glycol, PEG

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)

About This Item

Lineáris képlet:
H(OCH2CH2)nOH
CAS-szám:
25322-68-3
MDL-szám:
MFCD00081839
UNSPSC kód:
12352104
PubChem Substance ID:
24898275
NACRES:
NA.23

product name

Poly(ethylene glycol), average mol wt 8,000, powder

form

powder

Minőségi szint

200

molekulatömeg

average mol wt 8,000

oldhatóság

water: soluble (PEG is soluble in water approximately 630 mg/ml, 20 °C)

sűrűség

1.0845 g/mL at 70 °C
1.0689 g/mL at 90 °C

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

Nemzetközi kémiai azonosító kulcs

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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Általános leírás

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response

Alkalmazás

Poly (ethylene glycol) can be used in the formulation of the drug to improve its dissolution rate and oral bioavailability.

PEG can be used for the effective isolation of edible nanoparticles (ENPs) which have excellent anti-cancer and anti-inflammatory activities. PEG is a crowding agent and forms a net-like mesh in which nanovesicles are trapped and precipitated. For example, ginger-derived ENPs are isolated using a PEG-based method which is cost-effective compared to ultracentrifugation.

PEG can be used as a precursor to synthesize degradable hydrogels for the controlled release of hydrophilic and high molecular weight pharmaceuticals.

Tulajdonságok és előnyök

  • Highstructural flexibility
  • Biocompatibility
  • Amphiphilicity
  • Highhydration capacity
  • Devoidof any steric hindrance

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Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
0000410345
0000410345
0000407365
0000403506
0000401077

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Dokumentumtár megtekintése

D E Corpet et al.
Cancer research, 60(12), 3160-3164 (2000-06-24)
We have previously shown that dietary polyethylene-glycol (PEG) suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of colon carcinogenesis. To determine the consistency of this preventive effect, we carried out a long-term study in rats fed the
Maofu Li et al.
BMC plant biology, 21(1), 57-57 (2021-01-23)
Strawberry (Fragaria × ananassa Duch.) is an important fruit crop worldwide. It was particularly sensitive to drought stress because of their fibrous and shallow root systems. Mutant rty of Arabidopsis thaliana ROOTY (RTY) results in increased endogenous auxin levels, more
Parveen K Garg et al.
Atherosclerosis, 297, 81-86 (2020-02-26)
We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD). CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of
Leslie Y Beh et al.
Cell, 177(7), 1781-1796 (2019-05-21)
DNA N6-adenine methylation (6mA) has recently been described in diverse eukaryotes, spanning unicellular organisms to metazoa. Here, we report a DNA 6mA methyltransferase complex in ciliates, termed MTA1c. It consists of two MT-A70 proteins and two homeobox-like DNA-binding proteins and
Lisa F Horowitz et al.
Lab on a chip, 21(1), 122-142 (2020-11-12)
As preclinical animal tests often do not accurately predict drug effects later observed in humans, most drugs under development fail to reach the market. Thus there is a critical need for functional drug testing platforms that use human, intact tissues
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