The molecular weight and aldehyde content are variable and reported in the lot specific Certificate of Analysis. A review of recent lots reveals a molecular weight range of 35 - 45 kDa and an aldehyde content of 22 - 24 mole%. However, these are reported values and not required specifications. Please see the link below to access a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/aldrich/901777#product-documentation
Összes fotó(1)
Fontos dokumentumok
901777
Poly(M(EO)2MA:Poly(OEGMA)
(90:10), aldehyde functionalized, 25 wt% solution in water
Szinonimák:
PEGMA-co-POEGMA
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Lineáris képlet:
[CH2CCH3(COO(CH2CH2O)2CH3)]n[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CCH3(CONHCH2COH)]q
UNSPSC kód:
12162002
NACRES:
NA.23
Az árazás és az elérhetőség jelenleg nem elérhető
Javasolt termékek
Forma
solution
adagolási arány
(90:10)
szín
clear colorless to pale yellow
tárolási hőmérséklet
2-8°C
Related Categories
Általános leírás
In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized PM(EO)2MA-co-OEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA or PM(EO)2MA-co-OEGMA for rapid gelation via reversible hydrazone bond formation[1]. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants[2][3]. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.[4][5]
Poly(diethylene glycol methacrylate)-co-(oligoethylene glycol methacrylate), (PM(EO)2MA-co-OEGMA) is a comb-shaped, graft copolymer consisting of hydrophilic oligomer polyethylene glycol (PEG) chains grafted to a hydrophobic polymethacrylate backbone. In this material, the PEG chains are either diethylene glycol units or oligomer PEG (n=8-9) units. Resulting material properties can be tuned by controlling the ratio of each component. POEGMA has been suggested as a viable alternative to PEG in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates[6][7], enhance the stability and gene silencing efficiency of siRNAs[8], as an anti-fouling surface for biosensors[9], and eliminate PEG antigenicity[10][11].
Elkészítési megjegyzés
This product is provided as a 25 wt%solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution instructions and hydrogel preparation instructions.
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Weiping Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15231-15236 (2009-08-27)
The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the protein with a monodisperse polymer, with good retention of protein activity, significantly improved pharmacokinetics and increased bioavailability, and hence
Niels M B Smeets et al.
Chemical communications (Cambridge, England), 50(25), 3306-3309 (2014-02-18)
Injectable PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) have been developed based on complementary hydrazide and aldehyde reactive linear polymer precursors. These hydrogels display the desired biological properties of PEG, form covalent networks in situ following injection, and are easily
Imran Ozer et al.
Biomacromolecules, 18(9), 2699-2710 (2017-08-05)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity
Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 35469-35486 (2015)
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For product 901777, what's the molecular weight of this polymer, and how many aldehyde groups in the polymer? thanks!
1 answer-
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