901776
Poly(OEGMA)
hydrazide functionalized, 25 wt% solution in water
Szinonimák:
PEGMA, POEGMA
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
1 G
113 000,00 Ft
113 000,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Erről a tételről
Lineáris képlet:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CHCONHNHCO(CH2)4CONHNH2]p
UNSPSC kód:
12162002
NACRES:
NA.23
Ugrás ide:
Műszaki ügyfélszolgálat
Segítségre van szüksége? Szakértő tudósaink csapata készséggel áll az Ön rendelkezésére.
Segíthetünk?Forma
solution
molekulatömeg
~20,000 g/mol
szín
clear colorless to pale yellow
funkcionális csoport
hydrazide
tárolási hőmérséklet
2-8°C
Kapcsolódó kategóriák
1 of 4
Ez a tétel | 901777 | 901546 | P2139 |
|---|---|---|---|
| functional group hydrazide | functional group - | functional group hydrazide | functional group - |
| form solution | form solution | form solution | form powder |
| mol wt ~20,000 g/mol | mol wt - | mol wt Mw ~20,000 g/mol | mol wt average mol wt 8,000 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| color clear colorless to pale yellow | color clear colorless to pale yellow | color clear colorless to pale yellow | color - |
Általános leírás
Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly (ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates,[1][2] enhance the stability and gene silencing efficiency of siRNAs,[3] as an anti-fouling surface for biosensors,[4] and eliminate PEG antigenicity.[5][6] In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized POEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation.[7] Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants.[8][9] In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.[10][11]
Elkészítési megjegyzés
This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Reactive electro spinning of degradable poly(oligoethylene glycol methacrylate)-based nanofibrous hydrogel networks.
Xu F, et al.
Chemical Communications (Cambridge, England), 52, 1451-1454 (2016)
A. brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nmr in Biomedicine, 1, 0002-0002 (2016)
A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Niels M B Smeets et al.
Chemical communications (Cambridge, England), 50(25), 3306-3309 (2014-02-18)
Injectable PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) have been developed based on complementary hydrazide and aldehyde reactive linear polymer precursors. These hydrogels display the desired biological properties of PEG, form covalent networks in situ following injection, and are easily
Imran Ozer et al.
Biomacromolecules, 18(9), 2699-2710 (2017-08-05)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity
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