440744

Polycaprolactone

average M_n 80,000

• Szinonimák: 2-Oxepanone homopolymer, 6-Caprolactone polymer
• Lineáris képlet: (C₆H₁₀O₂)_n
• UNSPSC kód: 12162002
• NACRES: NA.23

Tulajdonságok

• Forma: pellets (~3 mm)
• Minőségi szint: 200
• molekulatömeg: average M_n 80,000
• szennyeződések: <0.5% water
• mp: 60 °C (lit.)
• sűrűség: 1.145 g/mL at 25 °C
• Mw/Mn: <2
• alkalmazás(ok): 3D bioprinting; advanced drug delivery
• SMILES string: C1CCC(=O)OCC1 (Canonical-SMILES)
• InChI: 1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2
• Nemzetközi kémiai azonosító kulcs: PAPBSGBWRJIAAV-UHFFFAOYSA-N

Leírás

Általános leírás

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:

• It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
• Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.

Alkalmazás

• PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
• Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
• PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
• Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
• Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

Tulajdonságok és előnyök

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)