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408719

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~800 by LS, average Mn ~600 by GPC

Szinonimák:

PEI, ethylenediamine branched

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)

About This Item

Lineáris képlet:
H(NHCH2CH2)nNH2
CAS-szám:
25987-06-8
MDL-szám:
MFCD00084427
UNSPSC kód:
12162002
NACRES:
NA.23

form

viscous liquid

Minőségi szint

200

molekulatömeg

average Mn ~600 by GPC
average Mw ~800 by LS

törésmutató

n20/D 1.5240

sűrűség

1.050 g/mL at 25 °C

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

Nemzetközi kémiai azonosító kulcs

SFLOAOINZSFFAE-UHFFFAOYSA-N

Related Categories

Általános leírás

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Alkalmazás

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO2 adsorbent. Numerous amino groups present in PEI can react with CO2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Tulajdonságok és előnyök

  • Branched PEI has better complexation and buffering capacity.
  • High ion exchange capacity and affinity toward proteins.
  • SignificantDNA transfer efficiency.

Fizikai forma

Branched polymer

Figyelmeztetés

Danger

Figyelmeztető mondatok

H302,H318,H411

Veszélyességi osztályok

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 3

Lobbanási pont (F)

356.0 °F

Lobbanási pont (C)

180 °C

Egyéni védőeszköz

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
WXBF4895V
MKCV6718
MKCJ2767
MKCG7251
MKCG3800

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COA keresése

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Dokumentumtár megtekintése

Valentina Dinca et al.
Sensors (Basel, Switzerland), 18(12) (2018-12-07)
Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic
Irena Mamajanov et al.
Life (Basel, Switzerland), 10(8) (2020-08-23)
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes:
Andrew Jajack et al.
PloS one, 14(1), e0210286-e0210286 (2019-01-17)
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Anna Alhaddad et al.
PloS one, 7(12), e52207-e52207 (2013-01-04)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic
Jonathon M Muncie et al.
Developmental cell, 55(6), 679-694 (2020-11-19)
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by modifying
View All Related Papers

Cikkek

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Polyelectrolyte Multilayer Films and Membrane Functionalization

We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.

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