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Merck
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408727

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched

Szinonimák:

aziridine, homopolymer, PEI

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)

About This Item

Lineáris képlet:
H(NHCH2CH2)nNH2
CAS-szám:
9002-98-6
MDL-szám:
MFCD00084427
UNSPSC kód:
12162002
PubChem Substance ID:
24865591
NACRES:
NA.23

Minőségi szint

200

form

viscous liquid

molekulatömeg

average Mn ~10,000 by GPC
average Mw ~25,000 by LS

szennyeződések

≤1% water

törésmutató

n20/D 1.5290

viszkozitás

13,000-18,000(50 °C)

bp

250 °C (lit.)

sűrűség

1.030 g/mL at 25 °C

SMILES string

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

Nemzetközi kémiai azonosító kulcs

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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Általános leírás

Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.

Alkalmazás

Polyethyleneimine can be used as a non-viral synthetic polymer vector for in vivo delivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.

PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2 absorption and gene delivery.

Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.

Tulajdonságok és előnyök

Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties.

Branched PEI has better complexation andbuffering capacity.

Fizikai forma

Branched polymer

Piktogramok

Exclamation markEnvironment
GHS07,GHS09

Figyelmeztetés

Warning

Figyelmeztető mondatok

H302,H317,H319,H411

Veszélyességi osztályok

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 2

Egyéni védőeszköz

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
BCCM5483
BCCM5482
BCCM2321
STBL4117
STBL2116

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Dokumentumtár megtekintése

Jessel, N., et al.
Polym. Mater. Sci. Eng., 90, 755-755 (2004)
Hsuan-Wen Chiu et al.
Oncotarget, 8(55), 94129-94141 (2017-12-08)
The betanodavirus B2 protein targets the mitochondria and acts as a "death factor", but its effect on lung cancer cells is unknown. We examined the effect of the B2 protein on triggering apoptosis or necroptosis
Wei Dong et al.
Frontiers in immunology, 9, 2312-2312 (2018-10-26)
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune responses against heterologous virus strains in animal models. Here we investigated whether sequential immunization with antigenically distinct influenza vaccines can also provide cross-protection. To this end, we compared immune responses
Yi-Hsuan Lee et al.
Acta biomaterialia, 63, 210-226 (2017-09-14)
The development of osteochondral tissue engineering is an important issue for the treatment of traumatic injury or aging associated joint disease. However, the different compositions and mechanical properties of cartilage and subchondral bone show the complexity of this tissue interface
Baoshun Lin et al.
Medicine, 94(31), e1301-e1301 (2015-08-08)
As an immunotoxin, diphtheria toxin has been widely used in gene therapy and gene function assays for its roles in protein synthesis inhibition, and the aim of our study is to set up a nonintegrating lentiviral system for specific expression
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Cikkek

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Polyelectrolyte Multilayer Films and Membrane Functionalization

We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.

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